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HPV vaccine protects girls from cervical cancer

Is this true? Make your call, then see what the science says.

Short answer: Yes. The evidence supports this.

The science says Supported Strong evidence

The HPV vaccine prevents the infections that cause most cervical cancers, and it cuts cervical pre-cancer in trials and real-world programs. It works best when given early in adolescence. Cervical screening is still needed later in life.

AI-generated summary of the research cited · not reviewed by a medical professional · checked 23 October 2026 · How we check

What the research found

Cochrane systematic review (2018) of randomised trials looked at the vaccine's protection against cervical pre-cancer and HPV16/18 infection. These two HPV types cause about 70% of cervical cancers worldwide. A large 2015 randomised trial of 14,215 women aged 16 to 26 tested the 9-valent vaccine, which covers more cancer-causing types, against infection and pre-cancer.

A 2019 meta-analysis in The Lancet looked at real-world vaccination programs. It compared HPV infections, genital warts and cervical pre-cancer (CIN2+) before and after vaccination began. A 2022 BMJ review said trials and population studies clearly show the vaccine reduces cervical pre-cancer. It said this suggests the vaccine reduces cervical cancer itself. Cervical cancer takes 15 to 20 years to develop, so this is an expected effect, not yet a directly measured one.

A 2023 systematic review of 21 studies found the vaccine works best when given young. Effectiveness against HPV-related disease was about 74% to 93% for ages 9 to 14, and 12% to 90% for ages 15 to 18. In Australia, HPV infection in females aged 18 to 24 fell from 22.7% to 1.5% by 2015 after the school program began.

What it doesn’t mean

  • The vaccine does not cover every cancer-causing HPV type, so cervical screening is still recommended for women who were vaccinated. Women aged 25 to 74 who have ever been sexually active should have a Cervical Screening Test.
  • It works best before any exposure to HPV. Australian guidance says around 12 to 13 years is the best age, but catch-up is possible up to 25 years. Talk to a GP or child health nurse if your child has missed a dose or has a weakened immune system, as they may need 3 doses.

Sources

General information only, not medical advice. KIDS fact-checks are generated by AI from published research and are not reviewed by doctors or other health professionals. They can be wrong or out of date. Always talk to your GP or child’s doctor about your child, and call 000 in an emergency. Spotted a problem? Tell us.

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